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Best Spermidine Supplements of 2023

Main Image Courtesy of Nutra Ingredients.

Spermidine is a polyamine compound (an organic compound with two amino groups) has risen in recent years due to several holistic health benefits it can offer. Initially found in human sperm by a Dutch scientist in the 1600s, spermidine supplements are made from its precursor, Putrescine, and another polyamine associated with the cellular function, spermine. Polyamines play several valuable roles, which include apoptosis, cell growth, cell proliferation, and DNA stability. Spermidine is essential for healthy tissue growth and function due to its growth factors during cell division. 

The holistic health benefits of spermidine encompass disease prevention, support for male fertility, and even areas such as hair health, as well as enhancing the immune system's ability to combat diseases, including those like the coronavirus. Spermidine supplements are available to assist in enhancing overall well-being and promoting graceful aging.

In this article, we will be covering spermidine a little bit more in-depth with points that include:

  • Science of how spermidine works within our bodies
  • Benefits of spermidine supplements
  • Best spermidine supplements on the market today

Science Behind Spermidine 

Dietary supplements can help us provide our bodies with certain nutrients or protect us against deficiencies. With spermidine supplements, we take in various active ingredients that control the molecular pathways and how we age. Molecular and cellular damage will typically arise within our bodies as we age, and supplements like spermidine will focus on the aging process instead of aging itself. More specifically, spermidine will induce the process of cellular rejuvenation known as autophagy. During autophagy, cells will reuse old organelles to reach cellular renewal and reap those anti-aging benefits. 

Studies in animals, such as worms, flies, and mice, have demonstrated that supplementation with spermidine can extend lifespan and improve various age-related physiological functions. As stated before, Spermidine is involved in cell growth, proliferation, differentiation, and death. It is essential for the maintenance of cellular functions and has been associated with longevity and health benefits in several organisms. It has also been found that spermidine is an antioxidant and exhibits anti-inflammatory properties, by preventing oxidative stress from building up within the system as well as decreasing cytokines and the production of inflammatory molecules.

Where Can Spermidine Be Found?

Spermidine can be found in almost every single living organism, from animals, to plants all the way down to the microbial level with bacteria. It is vital for cellular homeostasis. Within the human system Spermidine was found first within human semen (which is how it got its name) but can also be found throughout the entire system. Spermidine can be found in our eukaryotic cells, which play a vital role in cell metabolism. Spermidine is also found in some foods and supplements that can be consumed as a tablet or powders containing varying concentration levels. 

Foods that contain high amounts of spermidine include the following:

  • Vegetables
  • Soybean Products
  • Cereals
  • Cheeses
  • Mushrooms

Spermidine Benefits

As mentioned previously, spermidine can provide several benefits to our holistic health. Spermidine exerts its positive influence by supporting cellular functions such as apoptosis, which is essential for the natural removal of damaged cells. Additionally, it aids in promoting healthy cell growth and proliferation, contributing to DNA stability, and thus plays a crucial role in overall well-being and the aging process. Understanding the mechanisms through which spermidine functions can shed light on its diverse health-enhancing effects. Keep reading for more in-depth explanations of the multitude of benefits of taking spermidine. 

May Prevent Aging Diseases

Along with a healthy diet and sufficient exercise to take care of physical health, longevity supplements like spermidine can increase our health and prospective life expectancy. Age-related diseases, such as cancer, metabolic disease, heart disease, and neurodegeneration, can be reduced due to a large spermidine intake. Since Spermidine supplements provide polyamines, this allows the body to synthesize these organic compounds to Spermidine. 

Spermidine dissolves amyloid-beta proteins through autophagy, which can have a neuroprotective effect against neurological issues like inflammation, ischemia, and oxidative stresses. Autophagy is the lysosome dependent process of the cells going through and removing any non-necessary or dysfunctional components of other cells, but when this process defects it can actually negatively affect the system and potentially cause cancers and neurodegenerative diseases. But autophagy, when maintaining cellular homeostasis properly, can provide positive results on neurodegeneration, improving memory and limiting cognitive decline by dissolving the amyloid-beta plaque of the brain. More plaque buildup increases the risk of developing a neurodegenerative disease like Alzheimer's. 

Promote Healthy Aging

Spermidine supplements can help with some of the physical signs of aging, which can promote things like thicker hair, longer lashes, and nail growth, as well as improvements in symptoms of wrinkles. In a study done with mice, it was shown that spermidine is most effective in skin anti-aging. Spermidine can promote healthy aging by stimulating the production of:

  • Collagen
  • Elastic and lipids in cells
  • Overall improvements in both skin structure and barrier function

The Autophagy process also is responsible for anti-aging properties as well, by removing any unwanted components within the system at a higher rate, the functions at the cellular level will increase in productivity. By that logic, the entire system will function better, before age has set in on the entire system. Spermidine has also shown to benefit cardiovascular health, immune system health and provides anti-cancer properties. Through the lens of aging, this is terrific. 

Promote Longevity 

To put it in scientific terms, spermidine can work to improve our longevity by preventing telomere attrition and stabilizing the mitochondrial DNA. Like all DNA, the mDNA in cells can mutate, leading to aging and reduced lifespan. This mutating DNA can be protected by spermidine and preserve its integrity, which can be helpful in longevity applications. It can also help prevent the end caps of chromones from shortening with age, directly affecting longevity. A study also revealed that supplements containing spermidine can protect cardiac tissue from damage caused by oxidative stress.

No matter how hard we try to avoid it, our body will eventually accumulate damage, referred to as the "hallmarks of aging." Through cellular renewal induced by the process referred to as autophagy, spermidine can help improve the more "aesthetic" signs of aging that promote longevity. 

Reproductive Fertility Improvement 

The use of sperm can help improve fertility in both men and women. Due to the rising cost of living, societal pressures, and the global population, many people are avoiding giving birth. They may also encounter various problems conceiving a child. When women reach the age of 45, menopause can begin. The ovaries can also age five times faster than other organs.

Spermidine has been studied as a potential fertility aid because it can prevent the buildup of reactive oxygen species (ROS) in the ovaries, which can damage the eggs.

In the ovaries, ROS can lead to the development of abnormal stem cells, which can prevent them from producing viable eggs. A study on spermidine's effects on the production of stem cells and autophagy revealed that it could reduce the damage caused by oxidative stress.

This supplement could be utilized in fertility therapies. While men do not experience the same decline in fertility as women during menopause, spermidine can still provide some benefits for male fertility. Since this substance was first found in semen, it plays an essential role in the production of sperm. The levels of this chemical are lower compared to fertile individuals and infertile men.

This supplement could be utilized in fertility therapies. While men do not experience the same decline in fertility as women during menopause, spermidine can still provide some benefits for male fertility. Since this substance was first found in semen, it plays an essential role in the production of sperm. The levels of this chemical are lower compared to fertile individuals in infertile men. 

Side Effects of Spermidine Supplements 

Although Spermidine supplements are very well tolerated by the human system it is always important to keep in mind the potential side effects of any supplement being added into your daily routine. These include-

  • Potential Allergic Reaction
  • Nausea
  • Vomiting 
  • Diarrhea

An Allergy to this supplement is very rare but possible and the other side effects are the body’s reaction to taking the supplement on an empty stomach. But for most individuals there will be no side effects whatsoever from adding this supplement. Remember to always communicate with your doctor when you are adding or removing substances so there are no adverse effects of the combinations between prescribed medications and supplementations. 

Top 7 Spermidine Supplements of 2023

Now that you're more familiar with the various benefits spermidine can offer, check out some of the top supplements that are out there on the market today! Spermidine supplements can be taken as a supplement or powder. 

What to Look For in High-Quality Spermidine:

  • Dose: Up to 8 mg per day is the recommended amount.
  • Organic: Spermidine gets extracted from various foods, and GMO products will concentrate on the toxins.
  • Harmful Ingredients: Companies can use toxic excipients, flow agents, binders, and fillers in spermidine supplements, so it's essential to check the label before you purchase a product. 
  • Facility: All products should be produced to GMP and ISO9001 standards.
  • Form: Spermidine can come in powder, topical, tablet, and capsule form.

Spermidine by Dr. Emil Nutrition

Spermidine by dr emil- 60 Capsules / 30-Day Supply

Dr. Emil’s Spermidine Supplements are some of the best on the market as of now. Improve cell rejuvenation for healthier aging. Spermidine is derived from wheat germ and aids cell rejuvenation to support healthy aging.

Benefits include: 

  • Rejuvenating properties
  • Boosting of the immune system
  • Reducing inflammation
  • Enhancing fasting

Shop Dr. Emil’s longevity-boosting Spermidine Supplement >>

Renue by Science Lipo Spermidine 

 Bottle of Spermidine Supplements
You can purchase these supplements today for $81.25, Image Courtesy of Renue by Science.

Stand-out qualities of this first supplement include:

  • The quality of Renue's products is first and foremost. They are made in FDA-approved facilities, and they display their lab results so you can be assured that everything is pure.
  • Unfortunately, spermidine is known to have poor bioavailability. This is because it can affect the absorption of nutrients in human bodies, but Renue's formulation utilizes a liposomal delivery system.
  • When spermidine molecules are encapsulated in a lipid coating, they can endure our digestion environment and reach our bloodstream.
  • The cost of many spermidine products is high due to its cutting-edge nature. But Renee's effect is more affordable and comes at 4 mg per serving. Receive excellent value while also receiving guaranteed quality with these supplements!

Longevity Labs SpermidineLife Extra+

http://Bottle of Spermidine capsules with text showing an award for the product
You can find these supplements for $188. More expensive, but you will receive one of the best quality products!  Image Courtesy of Amazon

Longevity Labs produces various types of spermidine products in Austria using a patented process. This method ensures that their product is pure and consistent. Their formulation also involves using other polyamines, such as spermine and micronutrients.

It's not a surprise that Longevity Labs is one of the top spermidine companies in the world. They have numerous awards and patents to support the work they have done. Longevity Labs' version is a higher dosage of spermidine than its original. 

Oxford Primeadine Spermidine

Image Displaying three bottles of supplements with the capsules as well
You can purchase these spermidine supplements to keep you on track for a three-month supply.  Image Courtesy of Oxford Healthspan

Primeadine's formula in their spermidine supplements is unique because it avoids unnecessary fillers and synthetic ingredients. Oxford Healthspan sources its raw materials from Japan, but the final product is manufactured in an FDA-certified facility.

Prebiotic fiber has been added to Primeadine to nourish the gut's Bacteroides and Fuso-producing bacteria, which increases spermidine levels in the body.The company's marketing campaign has revolved around the supplement's various aesthetic benefits, such as improving nails, fuller hair, glowing skin, and reducing wrinkles. Primeadine might be the next addition to your beauty routine!

Do Not Age Spermidine 

 Container of Spermidine supplements around a glass of water, vegetables and capsules. 
These spermidine supplements are completely vegan-friendly and can be sold in two quantities that consist of either 60 ($69) or 366 ($375). Image Courtesy of DoNotAge

One of the most popular longevity supplement companies today is Do Not Age (DNA). The company is known for its sirtuins-activating products, such as the SIRT6 activator. This unique product contains 400mg of wheat germ extract, which provides 4mg of spermidine. It also has 1 mg of Zinc Picolinate, up to 4 times more potent than competitors.

The company uses the GMP and ISO9001 standards to ensure its spermidine is produced and stored in the best possible conditions. Most companies also store their products in hot, humid warehouses. This can degrade and oxidize the supplement, preventing it from remaining potent. 

Double Wood Spermidine

 Bottle of Spermidine Supplements and capsules
You can purchase these supplements for a great price of $49.95. Image Courtesy of Double Wood.

You may be familiar with the company Double Wood if you're a user of other anti-aging supplements, such as NMN. Double Wood was one of the stand-out companies to make the supplement so popular and affordable. However, it's important to note that the company does not disclose much about its processes, safety testing, or purity.

According to the company, their capsules are lab-tested and manufactured in the U.S., though it's still being determined if they're pure. The Double Wood label claims that theirs are gluten-free and non-GMO.

Most brands use wheat germ as their spermidine source. Double Wood, on the other hand, makes it using Putrescine. Since there is currently little research on how this method works, we have yet to learn much about its benefits or how it can be absorbed. Each bottle of Double Wood's product comes with 120 capsules. 

SuperSmart Spermidine

 Bottle of Spermidine Supplements
You can purchase these supplements for a very reasonable price of $50. Image Courtesy of Supersmart.

Reducing cellular spermidine levels is one of the most common signs of aging. Supersmart Spermidine can help boost spermidine levels both naturally and healthily.

Other than a reasonable price of only $50, other main pros to these supplements include:

  • All-natural ingredients 
  • Completely vegan
  • Additive-free
  • Gluten-free
  • Nano-particle free
  • Fast shipping

Get Your Spermidine Today

Spermidine holds remarkable potential, particularly in its ability to contribute to healthy aging and mitigate the impact of age-related diseases. Its multifaceted benefits, encompassing the promotion of autophagy and its prominent anti-inflammatory properties, offer a plethora of advantages when incorporating spermidine supplements into your daily regimen. Beyond its holistic health benefits, spermidine can also enhance physical well-being, yielding desirable aesthetic effects such as improved hair thickness and accelerated nail growth. 

With so much to gain and a myriad of potential advantages, why not get started on the journey of exploring the positive impact of spermidine? Embrace the opportunity to experience the potential transformative benefits of spermidine by incorporating it into your daily routine today!

You should consult a licensed health care professional before starting any supplement, dietary, or exercise program, especially if you are pregnant or have any pre-existing injuries or medical conditions.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any diseases.